Limitations of TabPFN for High-Dimensional RNA-seq Analysis

Published in bioRxiv, 2025

Recommended citation: Agarwal, V., Li, O., Kassis, T. et al. (2025). Limitations of TabPFN for High-Dimensional RNA-seq Analysis. bioRxiv. https://biorxiv.org

We systematically evaluate TabPFN on high-dimensional RNA-seq classification tasks, identifying key limitations in scalability and performance compared to tree-based ensembles and neural baselines, and provide practical guidance for transcriptomics practitioners.